Made × BioCreative Partnership

Made × BioCreative
build status

Working reference for the team. The build has consolidated into Made Reporting UX — Campaign Hub, the live SSO Matrix, Search Optimization, and in-app Brain Chat now run as tabs in one operator surface. Build — apps, data, agents, heartbeat. Project Mgmt — Made AI OS frame, fleet → director map, workstreams. Method — LLM-OS architecture. Infrastructure: 5 compute surfaces, 50 agents, 18 Supabase projects.

Snapshot 2026-06-11 · BioCreative Strategies


/01

Where the build lives today

Four dimensions of the build. Operator apps on top, the data layer underneath, agents running between them, and the heartbeat keeping it all coordinated. Each tile drills into its own page.



/ Recently shipped

Recent momentum

What shipped through early June — the consolidation into Made Reporting UX.

SSO Matrix — LIVE, agent-resolved

The sso_messaging_framework (33 cells) now resolves through the made-sso-agent with a RAG self-improvement loop. Old outreach_messaging_matrix retired. Admin at /admin/messaging-framework with a Coverage Gaps panel.

2026-06-10

Campaign Hub canonicalized

13 canonical funnel statuses + a handoff lifecycle, ported from CARR (12 edge functions, MADE-PORT). One canonical outreach_messages table, one status language across Hub + Tasks.

2026-06-05

Outreach channels hardened — both send-paths

HeyReach webhook rewritten (v4.4) after a silent payload-shape crash dropped every event; HR-truth tiles now match HeyReach 1:1 (1,804 sent / 547 accepted / 30.3%). EmailBison brought to parity — reply capture 251/251, rep handoff loop on both channels.

2026-06-10

Brain Chat shipped in-app

Full-corpus chat at /madeai/brain-chat with persistent history + a provenance panel, wrapping brain-router-v3. Next: LiteLLM proxy → router consolidation → Pydantic container (MADE_BRAIN_BUILD_PLAN.md).

2026-06-11

Search Optimization (SEO/GEO) tab

New /search-optimization page under Marketing — Overview · SEO · Content · Backlinks · GEO/AI — mirroring BC's SEO/GEO harness as the made_sci tenant.

2026-06-05

Scoring + enrichment, as a system

MAS + buyer-segment + the new marketing-persona layer, the canonical account-contact system, and a two-agent entity-resolution layer (Stakeholder + MADE-ID registries, propose-only HITL).

2026-06-10


/03

Made Commercial AI team

The core team driving the partnership. Tasks pulled live from Hub DB — editable via Windsurf at any time. Project management hub →

Extended team · Tier 1

How BioCreative supports the team

Brian Elbert

Tier 5

Founder, BioCreative Strategies

Leads the BC side of the partnership end-to-end — the architectural counterpart to Joe’s commercial AI build. Built Made Minimal (Science Hub) from the ground up and supports all active builds across the team. Sets cadence, prioritizes projects, and brings the agent build-out to ground across every workstream.

  • ·Vision & portfolio alignment — weekly cadence with Joe, project sequencing across the 6 active workstreams, decision support on architecture trade-offs
  • ·Build execution — agent + app delivery alongside the team (Made-Ralph, SSO matrix integration, partnership dashboard, marketing director merge)
  • ·Cross-team enablement — runbooks, onboarding (Melody Windsurf migration, Greg ramp, Lucy marketing agent), AI capability ladder, shared tooling at every tier

BC operates as a teammate, not a vendor. Helps manage the overall app-build vision across departments. Supports Joe in getting custom builds over the finish line so the team can use them. Supports Greg, Lucy, Melody, Dustin individually on their workstreams. Pushes everyone’s AI capability forward through runbooks, shared tooling, and on-site work sessions. Built and maintains this dashboard as the working reference.

May 2025 → Oct 2025

Foundation era — CRM scaffolding, database build, web automation, outbound + LinkedIn ops

Nov 2025

Made Reporting UX shipped — first joint app live in production

Q1 2026

Made Minimal app, SSO matrix groundwork, weekly cadence with Joe established, operator 1:1s begin

Q2 2026

Made-Ralph entity resolution agent live, SSO matrix integrated with Joe’s positioning RAG, design port across apps

Now

Full agent-workforce alignment, this partnership dashboard, methodology codification, Tier 1–5 capability ladder

Meetings

131

Total confirmed
(Apr 2025 → today)

28

Recorded in
Fireflies (~20%)

3

In-person visits
(latest May 21)

26.2h

Recorded build
session time

Per operator · meetings

Joe 97
Dustin 52
Lucy 48
Melody 17
Greg 8

/04

Team AI capability progression

Every team member sits on this ladder at whatever level they want. Movement is always optional. Goal is comfort + effectiveness at the rung that matches the work, not pushing anyone up the ladder unless they want it.

Tier 1

UX User

Uses the apps and dashboards built by Brian + Joe. No code, no DB queries. Interacts via Made Minimal, Reporting UX, documents, and team-built tools.

Greg sits here today · extended team default.

Tier 2

Claude Desktop + Backend Access

Claude Desktop and basic tools with connections to the Made AI team’s build. Read-only documentation access. Future: MCP/API connections to query data or living agents. No code writing or building.

Lucy sits here today.

Tier 3

No-Code Builder

Claude Desktop + MCP to Supabase, Lovable, Claude Co-Work, and web-based dev tools. Builds agents and environments following the Karpathy method. Entirely no-code but with real backend access.

Melody sits here today · Greg’s trajectory.

Tier 4

Full IDE Backend

Windsurf, Google Antigravity, Cursor. Full database connections. Work within VPS-hosted virtual environments. Build the full agent workforce.

Dustin sits here today.

Beyond

Tier 5

Beyond the Ladder

Architecture-setters. Ship custom iOS apps, run video-generation pipelines, define the design language, build agents that build agents. Self-sustaining and self-extending — the ladder doesn’t bound them.

Brian & Joe sit here today.



/05

Methodology we’re building on

Two pillars define how everything is designed. Every harness, agent, app, and team interaction sits on this foundation.

Pillar 1

LLM as Operating System

The Karpathy framing — Software 3.0, where the model itself is the program. The LLM is no longer just a function call; it’s a processor running an operating system you compose at runtime. We design agents the same way you’d design an OS: modular contextual systems (wikis, CLAUDE.md docs) act as the instruction layer, persistent memory is the file system, and skills are the kernel modules.

Static LLM architecture is what makes this durable. Model-agnostic routing via LiteLLM means the underlying processor swaps freely — Claude, GPT, Gemini, Qwen — without any backend change. Self-developing agents plug into skills, databases, and apps over standard interfaces (MCP, tool-calling, structured I/O), so capability grows without rewrites.

Live signal · May 28, 2026

Opus 4.8 shipped yesterday. Every agent in our stack just got an exponential upgrade with zero backend changes. Routine work also gets cheaper as models progress — every harness compounds in cost-efficiency over time. That’s the architectural payoff.

Pillar 2

Context + Harness Engineering

The stack you build on top of the OS. Skills are the atomic unit — markdown docs that teach a single capability. Agents compose skills into intent-driven actors with their own context pack and tool access. Harnesses orchestrate agents into repeatable pipelines: inputs → agent loop → validated outputs → side effects.

Context engineering replaces prompt engineering. Instead of crafting a clever string, you compose at invocation time: pull the right CLAUDE.md, the right skill docs, the right reference data, the right prior state — assemble, run, persist. Harness engineering makes that composition reusable. The interconnections between agents are what turn a pile of tools into a working system.

Build pipeline

skills → agents → harnesses → operating system

Harness types we use

Different problems call for different orchestration patterns. We pick the lightest viable harness for the job and escalate when the contract demands it.

Claude SDK harnesses

Direct Anthropic SDK loops with native tool-calling. Best when you need autonomous, multi-turn reasoning with full model context and the lowest possible latency tax.

  • Autonomous enrichment loops (agents that propose, verify, and persist)
  • Long-running research tasks with tool budgets
  • Cases where structured output isn’t worth the schema overhead

Pydantic agent harnesses

Schema-validated agent stacks built on Pydantic AI. Strict typed I/O, automatic retries on validation failure, predictable contracts.

  • Production agents that hand structured data to other systems
  • Anywhere you need to trust the output shape without post-validation
  • Multi-agent workflows where outputs flow as inputs to downstream agents

YAML / Archon-defined harnesses

Declarative workflow definitions in a custom Archon YAML grammar. Composable, version-controlled, reusable across projects. The bulk of orchestrated multi-step work runs here.

  • Cross-system pipelines (database → LLM → output channel)
  • Workflows where the steps are stable but the inputs vary
  • Reusable recipes that ship between projects without code changes

n8n + webhook harnesses

Event-driven workflows for ingest, sync, and cron-style operations. Visual editor for non-engineers, full code escape hatches for edge cases. Bridges between systems where a full agent loop is overkill.

  • Webhook receivers (CRM updates, calendar events, form submissions)
  • Scheduled syncs between databases and SaaS tools
  • Bridge logic where you don’t need an LLM in the loop

Deep dives: Project Mgmt · LLM-OS


/06

Task Hub overview

All tasks flow through these stages. Distributed across team members and tracked in Hub DB.

Status breakdown

Distribution by owner